Dysregulated lipid metabolism in lymphangioleiomyomatosis pathogenesis as a paradigm of chronic lung diseases.
(Per leggere l’articolo clicca QUI)
Bernardelli C, Caretti A, Lesma E.
Front Med (Lausanne). 2023 Jan 19;10:1124008. doi: 10.3389/fmed.2023.1124008.
Pulmonary Langerhans Cell Histiocytosis and Lymphangioleiomyomatosis Have Circulating Cells With Loss of Heterozygosity
of the TSC2 Gene.
(Per leggere l’articolo clicca QUI)
Elia D, Torre O, Vasco C, Geginat J, Abrignani S, Bulgheroni E, Carelli E, Cassandro R, Pacheco-Rodriguez G, Steagall WK, Moss J, Harari S.
Chest. 2022 Aug;162(2):385-393. doi: 10.1016/j.chest.2022.02.032.
Primary TSC2-/meth Cells Induce Follicular Neogenesis in an Innovative TSC Mouse Model.
(Per leggere l’articolo clicca QUI)
Bernardelli C, Chiaramonte E, Ancona S, Sirchia SM, Cerri A, Lesma E.
Int J Mol Sci. 2022 Aug 26;23(17):9713. doi: 10.3390/ijms23179713.
LAM Cells as Potential Drivers of Senescence in Lymphangioleiomyomatosis Microenvironment.
(Per leggere l’articolo clicca QUI)
Bernardelli C, Ancona S, Lazzari M, Lettieri A, Selvaggio P, Massa V, Gervasini C, Di Marco F, Chiaramonte R, Lesma E.
Int J Mol Sci. 2022 Jun 24;23(13):7040. doi: 10.3390/ijms23137040.
Differential Modulation of Matrix Metalloproteinases-2 and -7 in LAM/TSC Cells.
(Per leggere l’articolo clicca QUI)
Ancona S, Orpianesi E, Bernardelli C, Chiaramonte E, Chiaramonte R, Terraneo S, Di Marco F, Lesma E.
Biomedicines. 2021 Nov 24;9(12):1760. doi: 10.3390/biomedicines9121760.
Exploring the Role of Matrix Metalloproteinases as Biomarkers in Sporadic Lymphangioleiomyomatosis and Tuberous Sclerosis Complex. A Pilot Study.
(Per leggere l’articolo clicca QUI)
Terraneo S, Lesma E, Ancona S, Imeri G, Palumbo G, Torre O, Giuliani L, Centanni S, Peron A, Tresoldi S, Cetrangolo P, Di Marco F.
Front Med (Lausanne). 2021 Apr 26;8:605909. doi: 10.3389/fmed.2021.605909
Improving Survival in Lymphangioleio-myomatosis: A 16-Year Observational Study in a Large Cohort of Patients.
(Per leggere l’articolo clicca QUI)
Harari S, Torre O, Elia D, Caminati A, Pelosi G, Specchia C, Zompatori M, Cassandro R.
Observational Study Respiration. 2021;100(10):989-999. doi: 10.1159/000516330
Natural history of incidental sporadic and tuberous sclerosis complex associated lymphangioleiomyomatosis.
(Per leggere l’articolo clicca QUI)
Di Marco F, Terraneo S, Dias OM, Imeri G, Centanni S, Rinaldo RF, Giuliani L, Lesma E, Palumbo G, Wanderley M, Ribeiro Carvalho CR, Guedes Baldi B. Respir Med. 2020 Jul;168:105993. doi: 10.1016/j.rmed.2020.105993.
Role of thoracic imaging in the management of lymphangioleiomyomatosis.
(Per leggere l’articolo clicca QUI)
Crivelli P, Ledda RE, Terraneo S, Conti M, Imeri G, Lesma E, Di Marco F.
Respiratory Medicine; 157: 14-20 (2019). DOI: 1016/j.rmed.2019.08.013.
Hemodynamic Mechanisms of Exercise-Induced Pulmonary Hypertension in Patients with Lymphangioleiomyomatosis: The Role of Exercise Stress Echocardiography.
(Per leggere l’articolo clicca QUI)
Sonaglioni A, Baravelli M, Cassandro R, Torre O, Elia D, Anzà C, Harari S.
J Am Soc Echocardiogr. 2018 Aug;31(8):888-901. doi: 10.1016/j.echo.2018.02.004.
Lymphangioleiomyomatosis, multifocal micronodular pneumocyte hyperplasia, and sarcoidosis: more pathological findings in the same chest CT, or a single pathological pathway?
(Per leggere l’articolo clicca QUI)
Di Marco F, Palumbo G, Terraneo S, Imeri G, Lesma E, Sverzellati N, Peron A, Gualandri L, Canevini MP, Centanni S.
BMC Pulm Med. 2017; 17(1):107. DOI: 10.1186/s12890-017-0447-x
Sirolimus Therapy for Patients with Lymphangioleiomyomatosis Leads to Loss of Chylous Ascites and Circulating LAM Cells
(Per leggere l’articolo clicca QUI)
Harari S, Elia D, Torre O, Bulgheroni E, Provasi E, Moss J.
Case Reports Chest. 2016 Aug;150(2):e29-32. doi: 10.1016/j.chest.2016.02.654
Women with TSC: Relationship between Clinical, Lung Function and Radiological Features in a Genotyped Population Investigated for Lymphangioleiomyomatosis
(Per leggere l’articolo clicca QUI)
Fabiano Di Marco, Silvia Terraneo, Gianluca Imeri, Giuseppina Palumbo, Francesca La Briola, Silvia Tresoldi, Angela Volpi, Lorenzo Gualandri, Filippo Ghelma, Rosa Maria Alfano, Emanuele Montanari, Alfredo Gorio, Elena Lesma, Angela Peron, Maria Paola Canevini, Stefano Centanni
PLOSE ONE, May 12, 2016
Anti-EGFR Antibody Reduces Lung Nodules by Inhibition of EGFR-Pathway in a Model of Lymphangioleiomyomatosis
(Per leggere l’articolo clicca QUI)
Elena Lesma, Eloisa Chiaramonte, Silvia Ancona, Emanuela Orpianesi, Anna Maria Di Giulio, and Alfredo Gorio
Hindawi Publishing Corporation BioMed Research International Volume 2015
TSC epigenetic defect in primary LAM cells. Evidence of an anchorage-indipendent survival.
(Per leggere l’articolo clicca QUI)
Elena Lesma, Silvia Ancona, Silvia M. Sirchia, Emanuela Orpianesi, Vera Grande, Patrizia Colapietro, Eloisa Chiaramonte, Anna Maria Di Giulio, Alfredo Gorio
J. Cell. Mol. Med. Vol 18, No 5, 2014 pp 766-779
Chromatin remodelling by rosuvastatin normalizes TSC2-/meth cell phenotype through the expression of tuberin.
(Per leggere l’articolo clicca QUI)
Lesma E., Ancona S., Orpianesi E., Grande V., Di Giulio AM., Gorio A.
J Pharmacol Exp Ther 2013; 345:180–188
Development of a Lymphangioleiomyomatosis model by endonasal administration of human TSC2-/- smooth muscle cells in mice.
(Per leggere l’articolo clicca QUI)
Lesma E., Chiaramonte E., Isaia E., Grande V., Ancona S., Orpianesi E., Di Giulio A.M., Gorio A.
Am J Pathol 181(3) : 947-960 (2012)
Development of a Lymphangioleiomyomatosis model by endonasal administration of human TSC2-/- smooth muscle cells in mice.
(Per leggere l’articolo clicca QUI)
Lesma E., Chiaramonte E., Isaia E., Grande V., Ancona S., Orpianesi E., Di Giulio A.M., Gorio A.
Am J Pathol 181(3) : 947-960 (2012)
Articoli pubblicati nel sito dell’Azienda Ospedaliera San Paolo di Milano – Polo Universitario:
Anti-EGFR Antibody Efficiently and Specifically Inhibits Human TSC2 -/- Smooth Muscle Cell Proliferation. Possible Treatment Options for TSC and LAM.
(Per leggere l’articolo clicca QUI)
Elena Lesma, Vera Grande, Silvia Ancona, Stephana Carelli, Anna Maria Di Giulio, Alfredo Gorio.
Articolo pubblicato su PLoS ONE. Ottobre 2008.
Isolation and growth of smooth muscle-like cells derived from tuberous sclerosis complex-2 human renal angiomyolipoma: epidermal growth factor is the required growth factor.
Lesma E, Grande V, Carelli S, Brancaccio D, Canevini MP, Alfano RM, Coggi G, Di Giulio AM, Gorio A.
Am J Pathol. 2005 Oct; 167(4):1093-103.
Lymphangioleiomyomatosis, multifocal micronodular pneumocyte hyperplasia, and sarcoidosis: more pathological findings in the same chest CT, or a single pathological pathway?
(Per leggere l’articolo clicca QUI)
Di Marco F, Palumbo G, Terraneo S, Imeri G, Lesma E, Sverzellati N, Peron A, Gualandri L, Canevini MP, Centanni S.
BMC Pulm Med. 2017; 17(1):107. DOI: 10.1186/s12890-017-0447-x
_________________________________________________________________________________________________
Sirolimus Therapy for Patients with Lymphangioleiomyomatosis Leads to Loss of Chylous Ascites and Circulating LAM Cells
(Per leggere l’articolo clicca QUI)
Harari S, Elia D, Torre O, Bulgheroni E, Provasi E, Moss J.
Case Reports Chest. 2016 Aug;150(2):e29-32. doi: 10.1016/j.chest.2016.02.654
Women with TSC: Relationship between Clinical, Lung Function and Radiological Features in a Genotyped Population Investigated for Lymphangioleiomyomatosis
(Per leggere l’articolo clicca QUI)
Fabiano Di Marco, Silvia Terraneo, Gianluca Imeri, Giuseppina Palumbo, Francesca La Briola, Silvia Tresoldi, Angela Volpi, Lorenzo Gualandri, Filippo Ghelma, Rosa Maria Alfano, Emanuele Montanari, Alfredo Gorio, Elena Lesma, Angela Peron, Maria Paola Canevini, Stefano Centanni
PLOSE ONE, May 12, 2016
Anti-EGFR Antibody Reduces Lung Nodules by Inhibition of EGFR-Pathway in a Model of Lymphangioleiomyomatosis
(Per leggere l’articolo clicca QUI)
Elena Lesma, Eloisa Chiaramonte, Silvia Ancona, Emanuela Orpianesi, Anna Maria Di Giulio, and Alfredo Gorio
Hindawi Publishing Corporation BioMed Research International Volume 2015
TSC epigenetic defect in primary LAM cells. Evidence of an anchorage-indipendent survival.
(Per leggere l’articolo clicca QUI)
Elena Lesma, Silvia Ancona, Silvia M. Sirchia, Emanuela Orpianesi, Vera Grande, Patrizia Colapietro, Eloisa Chiaramonte, Anna Maria Di Giulio, Alfredo Gorio
J. Cell. Mol. Med. Vol 18, No 5, 2014 pp 766-779
Chromatin remodelling by rosuvastatin normalizes TSC2-/meth cell phenotype through the expression of tuberin.
(Per leggere l’articolo clicca QUI)
Lesma E., Ancona S., Orpianesi E., Grande V., Di Giulio AM., Gorio A.
J Pharmacol Exp Ther 2013; 345:180–188
Development of a Lymphangioleiomyomatosis model by endonasal administration of human TSC2-/- smooth muscle cells in mice.
(Per leggere l’articolo clicca QUI)
Lesma E., Chiaramonte E., Isaia E., Grande V., Ancona S., Orpianesi E., Di Giulio A.M., Gorio A.
Am J Pathol 181(3) : 947-960 (2012)
Development of a Lymphangioleiomyomatosis model by endonasal administration of human TSC2-/- smooth muscle cells in mice.
(Per leggere l’articolo clicca QUI)
Lesma E., Chiaramonte E., Isaia E., Grande V., Ancona S., Orpianesi E., Di Giulio A.M., Gorio A.
Am J Pathol 181(3) : 947-960 (2012)
Articoli pubblicati nel sito dell’Azienda Ospedaliera San Paolo di Milano – Polo Universitario:
Anti-EGFR Antibody Efficiently and Specifically Inhibits Human TSC2 -/- Smooth Muscle Cell Proliferation. Possible Treatment Options for TSC and LAM.
(Per leggere l’articolo clicca QUI)
Elena Lesma, Vera Grande, Silvia Ancona, Stephana Carelli, Anna Maria Di Giulio, Alfredo Gorio.
Articolo pubblicato su PLoS ONE. Ottobre 2008.
Isolation and growth of smooth muscle-like cells derived from tuberous sclerosis complex-2 human renal angiomyolipoma: epidermal growth factor is the required growth factor.
Lesma E, Grande V, Carelli S, Brancaccio D, Canevini MP, Alfano RM, Coggi G, Di Giulio AM, Gorio A.
Am J Pathol. 2005 Oct; 167(4):1093-103.