Women with TSC: Relationship between Clinical, Lung Function and Radiological Features in a Genotyped Population Investigated for Lymphangioleiomyomatosis
(Per leggere l'articolo clicca QUI)
Fabiano Di Marco, Silvia Terraneo, Gianluca Imeri, Giuseppina Palumbo, Francesca La Briola, Silvia Tresoldi, Angela Volpi, Lorenzo Gualandri, Filippo Ghelma, Rosa Maria Alfano, Emanuele Montanari, Alfredo Gorio, Elena Lesma, Angela Peron, Maria Paola Canevini, Stefano Centanni
PLOSE ONE, May 12, 2016
TSC epigenetic defect in primary LAM cells. Evidence of an anchorage-indipendent survival.
(Per leggere l'articolo clicca QUI)
Elena Lesma, Silvia Ancona, Silvia M. Sirchia, Emanuela Orpianesi, Vera Grande, Patrizia Colapietro, Eloisa Chiaramonte, Anna Maria Di Giulio, Alfredo Gorio
J. Cell. Mol. Med. Vol 18, No 5, 2014 pp 766-779

  • references compa
Anti-EGFR Antibody Reduces Lung Nodules by Inhibition of EGFR-Pathway in a Model of Lymphangioleiomyomatosis
(Per leggere l'articolo clicca QUI)
Elena Lesma, Eloisa Chiaramonte, Silvia Ancona, Emanuela Orpianesi, Anna Maria Di Giulio, and Alfredo Gorio
Hindawi Publishing Corporation BioMed Research International Volume 2015
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Chromatin remodelling by rosuvastatin normalizes TSC2-/meth cell phenotype through the expression of tuberin.
(Per leggere l'articolo clicca QUI)
Lesma E., Ancona S., Orpianesi E., Grande V., Di Giulio AM., Gorio A.
J Pharmacol Exp Ther 2013; 345:180–188
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Development of a Lymphangioleiomyomatosis model by endonasal administration of human TSC2-/- smooth muscle cells in mice.
(Per leggere l'articolo clicca QUI)
Lesma E., Chiaramonte E., Isaia E., Grande V., Ancona S., Orpianesi E., Di Giulio A.M., Gorio A.
Am J Pathol 181(3) : 947-960 (2012)
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Lymphangioleiomyomatosis and TSC2-/- Cells.
Thomas N. Darling, Gustavo Pacheco-Rodriguez, Alfredo Gorio, Elena Lesma, Cheryl Walker, Joel Moss.
Articolo pubblicato su LYMPHATIC RESEARCH AND BIOLOGY. Febbraio 2010.
The Methylation of the TSC2 Promoter Underlies the Abnormal Growth of TSC2 Angiomyolipoma-Derived Smooth Muscle Cells.
Elena Lesma, Silvia Maria Sirchia, Silvia Ancona, Stephana Carelli, Silvano Bosari, Filippo Ghelma, Emanuele Montanari, Anna Maria Di Giulio, Alfredo Gorio.
Articolo pubblicato su The American Journal of Pathology. Giugno 2009.
Articoli pubblicati nel sito dell’Azienda Ospedaliera San Paolo di Milano - Polo Universitario:

Prestigioso premio (ATS/LAM Foundation Award 2009) riconosciuto alla dott.ssa Elena Lesma.
Aprile 2009
Articolo pubblicato su ATS (America Thoracic Society) News.
Vedi a pag. 9 (3,12 Mb)
Anti-EGFR Antibody Efficiently and Specifically Inhibits Human TSC2 -/- Smooth Muscle Cell Proliferation. Possible Treatment Options for TSC and LAM.
(Per leggere l'articolo clicca QUI)
Elena Lesma, Vera Grande, Silvia Ancona, Stephana Carelli, Anna Maria Di Giulio, Alfredo Gorio.
Articolo pubblicato su PLoS ONE. Ottobre 2008.
Isolation and growth of smooth muscle-like cells derived from tuberous sclerosis complex-2 human renal angiomyolipoma: epidermal growth factor is the required growth factor.
Lesma E, Grande V, Carelli S, Brancaccio D, Canevini MP, Alfano RM, Coggi G, Di Giulio AM, Gorio A.
Am J Pathol. 2005 Oct; 167(4):1093-103.
Statins in Lymphangioleiomyomatosis. Simvastatin and Atorvastatin Induce Differential Effects on tuberous sclerosis complex 2-Null Cell Growth and Signaling.
Atochina-Vasserman EN, Goncharov DA, Volgina AV, Milavec M, James ML, Krymskaya VP.
Am J Respir Cell Mol Biol. 2013 Nov;49(5):704-9.
A pilot study assessing the effect of bronchodilator on dynamic hyperinflation in LAM.
Baldi BG, de Albuquerque AL, Pimenta SP, Salge JM, Kairalla RA, Carvalho CR.
Respir Med. 2013 Nov;107(11):1773-80.
Right Native Lung Pneumonectomy Due to over Inflation Three Years after Left Single Lung Transplantation for Pulmonary Lymphangioleiomyomatosis.
Liu F, Ruan Z, Wang S, Lin Q.
Ann Thorac Cardiovasc Surg. 2013 Oct 3
Sirolimus decreases circulating LAM cells in patients with lymphangioleiomyomatosis.
Cai X, Pacheco-Rodriguez G, Haughey M, Samsel L, Xu S, Wu HP, McCoy JP, Stylianou M, Darling TN, Moss J.
Chest. 2013 Sep 19. [Epub ahead of print]
Sex-specific lung diseases: effect of oestrogen on cultured cells and in animal models.
Shim B, Pacheco-Rodriguez G, Kato J, Darling TN, Vaughan M, Moss J.
Eur Respir Rev. 2013 Sep 1;22(129):302-11.
Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis.
Gu X, Yu JJ, Ilter D, Blenis N, Henske EP, Blenis J.
Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14960-5.
Osteoprotegerin contributes to the metastatic potential of cells with a dysfunctional TSC2 tumor-suppressor gene.
Steagall WK, Pacheco-Rodriguez G, Glasgow CG, Ikeda Y, Lin JP, Zheng G, Moss J.
Am J Pathol. 2013 Sep;183(3):938-50.
Uterine-specific loss of Tsc2 leads to myometrial tumors in both the uterus and lungs.
Prizant H, Sen A, Light A, Cho SN, DeMayo FJ, Lydon JP, Hammes SR.
Mol Endocrinol. 2013 Sep;27(9):1403-14.
Serum VEGF-D concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) trial.
Young LR, Lee HS, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP 3rd, Goldberg HJ, Downey GP, Swigris JJ, Taveira-Dasilva AM, Krischer JP, Trapnell BC, McCormack FX.
Lancet Respir Med. 2013 Aug;1(6):445-452
Characterization of lymphangioleiomyomatosis as a neoplastic disease.
Burger CD.
Am J Respir Crit Care Med. 2013 Aug 1;188(3):398.
Prevalence and clinical features of lymphedema in patients with lymphangioleiomyomatosis.
Hoshika Y, Hamamoto T, Sato K, Eto H, Kuriyama S, Yoshimi K, Iwakami S, Takahashi K, Seyama K.
Respir Med. 2013 Aug;107(8):1253-9.
Positioning ganglioside D3 as an immunotherapeutic target in lymphangioleiomyomatosis.
Gilbert ER, Eby JM, Hammer AM, Klarquist J, Christensen DG, Barfuss AJ, Boissy RE, Picken MM, Love RB, Dilling DF, Le Poole IC.
Am J Pathol. 2013 Jul;183(1):226-34.